{"id":857,"date":"2017-07-11T12:56:54","date_gmt":"2017-07-11T10:56:54","guid":{"rendered":"https:\/\/pharmpur.de\/produkte\/"},"modified":"2020-05-01T17:39:19","modified_gmt":"2020-05-01T15:39:19","slug":"produkte","status":"publish","type":"page","link":"https:\/\/pharmpur.de\/en\/produkte\/","title":{"rendered":"Products"},"content":{"rendered":"

[vc_row][vc_column][rev_slider_vc alias=\u201dprodukte_slider\u201d rev_slider_bg=\u201dLight\u201d][\/vc_column][\/vc_row][vc_row][vc_column width=\u201d1\/4\u2033][\/vc_column][vc_column width=\u201d1\/2\u2033][vc_column_text]<\/p>\n

Perfluo\u00adro\u00adcarbon Liquids<\/h2>\n

Perfluo\u00adro\u00adcarbon liquids (PFCLs) are organic compounds in which all H-atoms are replaced by F-atoms. Due to the F-atoms\u2019 electronic structure and arran\u00adgement, an almost-complete shield of the molecules is achieved. The compounds are chemi\u00adcally inert. With their low surface tension, low conduc\u00adtivity and high density, their highly solvent properties for gases (oxygen and carbon dioxide) make PFCLs very suitable for different medical applications.[\/vc_column_text][\/vc_column][vc_column width=\u201d1\/4\u2033][\/vc_column][\/vc_row][vc_row full_width=\u201dstretch_row\u201d el_class=\u201dimageRow\u201d css=\u201d.vc_custom_1502350023600{background-image: url(https:\/\/pharmpur.de\/wp-content\/uploads\/2017\/07\/Produkte_523_Silikonruehrer85.jpg?id=365) !important;}\u201d][vc_column][\/vc_column][\/vc_row][vc_row][vc_column width=\u201d1\/4\u2033][\/vc_column][vc_column width=\u201d1\/2\u2033][vc_column_text]<\/p>\n

Need to purify PFCL<\/h2>\n

Due to the manufac\u00adturing process, perfluo\u00adro\u00adcarbon liquids (PFCL) contain incom\u00adpletely fluori\u00adnated particles and fluoric olefins that are toxic. The toxicity level depends on the compounds\u2019 structure, and is dose-dependent.
\nPharmpur conducts a specific, individual purifi\u00adcation process for each PFCL, and the success of each proce\u00addural stage is analy\u00adti\u00adcally controlled.[\/vc_column_text][\/vc_column][vc_column width=\u201d1\/4\u2033][\/vc_column][\/vc_row][vc_row][vc_column width=\u201d1\/4\u2033][\/vc_column][vc_column width=\u201d1\/2\u2033][vc_column_text]<\/p>\n

The H-value Quality Criterion<\/h3>\n

H-Value<\/h5>\n

[\/vc_column_text][vc_column_text]Impurities in PFCL that have been incom\u00adpletely fluori\u00adnated can be quantified as the source of toxic side effects via the H-value. The elimi\u00adnation of residual protons in the form of HF is enacted via strong chemical bases, and the amount of separated fluoride is deter\u00admined. Finally, it is back-calcu\u00adlated to the reaction\u2019s origin \u2013 the proton concen\u00adtration. The threshold value for safe appli\u00adcation of PFCL is 10 ppm.[\/vc_column_text][\/vc_column][vc_column width=\u201d1\/4\u2033][\/vc_column][\/vc_row][vc_row][vc_column width=\u201d1\/4\u2033][\/vc_column][vc_column width=\u201d1\/2\u2033][vc_column_text]<\/p>\n

Silicone Oils<\/h2>\n

Silicones and silicone oils are widely used in medicine. For direct implan\u00adtation, e.g. when used for ocular endotam\u00adpo\u00adnades, an especially high degree of purity is required. Impurities origi\u00adnating during production, such as residual OH-groups (incom\u00adplete endcapping), ionic compounds (catalysts) and oligosil\u00ado\u00adxanes are only tolerable in the trace range. This is ensured by a special method developed by Pharmpur.[\/vc_column_text][\/vc_column][vc_column width=\u201d1\/4\u2033][\/vc_column][\/vc_row][vc_row][vc_column width=\u201d1\/4\u2033][\/vc_column][vc_column width=\u201d1\/2\u2033][vc_column_text]<\/p>\n

Oligosil\u00adoxane Content<\/h3>\n

Oligosil\u00ado\u00adxanes are low-molecular components of silicone oil that are generated during the production process. Because of their toxic properties and high suscep\u00adti\u00adbility to diffusing into surrounding tissue, these components must be removed before being adminis\u00adtered as an ocular endotam\u00adponade. This is ensured by a special method developed by Pharmpur.[\/vc_column_text][\/vc_column][vc_column width=\u201d1\/4\u2033][\/vc_column][\/vc_row][vc_row][vc_column width=\u201d1\/4\u2033][\/vc_column][vc_column width=\u201d1\/2\u2033][vc_column_text]<\/p>\n

Viscous Media<\/h2>\n

Pharmpur produces various gel-like substances with very different rheolo\u00adgical properties that are charac\u00adte\u00adrised by very low endotoxin content. The production of these products is conti\u00adnuously controlled via rheolo\u00adgical analyses. For classi\u00adfying the products used in ophthal\u00admology, an individual concept was developed based on rheolo\u00adgi\u00adcally-measured values.[\/vc_column_text][\/vc_column][vc_column width=\u201d1\/4\u2033][\/vc_column][\/vc_row][vc_row full_width=\u201dstretch_row\u201d content_placement=\u201dtop\u201d el_class=\u201dtableRow\u201d css=\u201d.vc_custom_1502979972648{background-color: #ededee !important;}\u201d][vc_column width=\u201d1\/4\u2033][\/vc_column][vc_column width=\u201d1\/4\u2033][vc_column_text]<\/p>\n